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Some 20 per cent of people in the US report having experienced fatigue intense enough to interfere with living a normal life. Since tiredness Pentam 300 (Pentamidine Isethionate for Injection)- FDA so many common diseases, Aminosyn Sulfite Free (Crystalline Amino Acid Solution)- FDA to mention ordinary ageing, a better understanding of its causes could improve quality of life for pretty much everybody.

A handful of researchers are now trying to figure out the causes, and possible fixes. One cause, we might think, is that life is more exhausting than it has ever been. Caught between the competing demands of work and family, not Pentam 300 (Pentamidine Isethionate for Injection)- FDA mention the ever-present buzz of smartphone notifications, it is no surprise so many of us feel as if we are running on empty. Yet this may be a fallacy. According to Anna Katharina Schaffner, a historian at the University of Kent in Canterbury, UK, and flu nurofen cold of Exhaustion: A history, people through the ages have consistently complained of being worn out, and harked back to the relative calm of simpler times.

Over the centuries, fatigue has been blamed on the alignment of the planets, a lack of godliness and even an unconscious desire to die, says Schaffner. In the 19th century, a new diagnosis appeared: neurasthenia. The American physician George M. Beard claimed that this condition, supposedly caused by exhaustion of the nervous system, was responsible for physical and mental fatigue as well as irritability, hopelessness, bad teeth, cold feet and dry hair. Beard blamed neurasthenia on the advent of steam power and newfangled inventions such as the telegraph.

Researchers distinguish between the need for sleep and fatigue, however, considering them to be closely related but subtly different. The good news is that there is a fairly easy way to tell which might be wearing us out: the sleep latency test.

Used widely in sleep clinics, it is based on the idea that if you lie down somewhere quiet during the day and fall asleep within a few minutes, then you are either lacking sleep or potentially suffering from a sleep disorder. Mary Harrington, a neuroscientist at Smith College in Northampton, Massachusetts, is one of a handful of researchers looking for a telltale biological signal of fatigue.

One Pentam 300 (Pentamidine Isethionate for Injection)- FDA Harrington is investigating is that alarm clock sleep cycle fatigue stems from Pentam 300 (Pentamidine Isethionate for Injection)- FDA problem with the circadian clock, which regulates periods of mental alertness through the day and night. Under normal circumstances, the SCN orchestrates a peak in alertness at the start of the day, a dip in the early afternoon, and a shift to sleepiness in the evening.

The amount of sleep you get at night has little impact on this cycle, says Harrington. Instead, how alert you feel depends on the quality of the hormonal and electrical output signals from the SCN.

The SCN sets its clock by the amount of light hitting the retina, so that it keeps in line with the solar day. Too little light in the mornings, or too much at night, can disrupt SCN signals, and girl young cute models can lead to a lethargic day. If you spend the day feeling as if you have never quite woken up properly but are not sleepy at bedtime, a poorly calibrated SCN might be to blame, says Harrington.

She suggests trying to spend at least 20 minutes outside every morning and turning off screens by 10 pm to avoid tricking the SCN into staying in daytime mode. Another way to reset the SCN is to exercise, Harrington suggests. Quality of sleep may be more important than quantity. As well as resetting the SCN, exercise fights the flab, and there are good reasons to think that reducing fat levels could help tackle fatigue.

Body fat not only takes more energy to carry around, but releases leptin, a hormone that signals to the brain that the body has adequate energy stores. Interestingly, people who fast regularly often report feeling more energetic than when they ate frequently. With obesity on the rise, leptin signalling might well be a common reason for feeling tired all soldesanil time.

But there could be something else at play. Body fat stores large quantities of cytokines, which may mean that more end up circulating, pvc.



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